b'MDD as well as the severity of symptoms tend to increase over time. Untreated MDD can be tremendously debilitating and is believed to significantly increase risk for suicide. Symptoms of MDD The onset of the first episode of major depression may not be obvious if it is gradual or mild. The symptoms of MDD characteristically represent a significant change from previous functioning. The symptoms include: persistently sad or irritable mood pronounced changes in sleep, appetite, and energy difficulty thinking, concentrating, and remembering physical slowing or agitation lack of interest in or pleasure from activities that were once enjoyed feelings of guilt, worthlessness, hopelessness, and emptiness recurrent thoughts of death or suicide persistent physical symptoms that do not respond to treatment, such as headaches, digestive disorders, and chronic pain When several of these symptoms of depressive illness occur at the same time, last longer than two weeks and interfere with ordinary functioning, professional treatment is needed.Mental Health Concerns160'